Neurofibrillary Tangle Predominant Dementia: Clinical and Pathological
Description in a Case Series
 
   Lead Investigator:    Geidy Serrano
   Institution      :    Banner Sun Health Research Institute
   E-Mail           :    geidy.serrano@bannerhealth.com
   Proposal ID      :    552



   Proposal Description:
   Neurofibrillary tangle predominant dementia (NFTPD) is classified as a sporadic subtype of progressive dementia affecting elderly patients defined by the presence of pathological neurofibrillary tangles (NFT) in limbic areas, usually NFT Braak stage IV and without any or minimal senile amyolid plaques through the brain. This type of dementia is not well characterized because only 0.7 to  5.8 of clinically diagnosed demented cases are pathologically diagnosed as NFTPD. The goal of the current study is to investigate the clinical characteristics of NFTPD to potentially identify key clinical features of the dementia.